Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis.

Limitation of (1→3)-β-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass

cated for detection of invasive candidiasis. Our data indicate that the rate o f false positive results is potentially high in some patient collectives of risk; for example, after cardiac artery bypass grafting (CABG). Th e recently published guidelines from the Surviving Sepsis Campaign recommend the use of (13)-β-dglucan as a surrogate for invasive candidiasis [1]. Fung al infections are inc...

Reply to "Why should we monitor (1-3)-β-D-glucan levels during invasive candidiasis? Just ask your ophthalmologist!".

The incidence of ocular involvement in patients with candidemia, especially endophthalmitis, is relatively low. Patients who have a longer duration of candidemia have higher risk of developing ocular candidiasis (1). The current Infectious Diseases Society of America clinical practice guidelines (2) recommend that patients with candidemia should have at least one dilated retinal examination dur...

Invasive Candidiasis in Various Patient Populations: Incorporating Non-Culture Diagnostic Tests into Rational Management Strategies

Mortality rates due to invasive candidiasis remain unacceptably high, in part because the poor sensitivity and slow turn-around time of cultures delay the initiation of antifungal treatment. β-d-glucan (Fungitell) and polymerase chain reaction (PCR)-based (T2Candida) assays are FDA-approved adjuncts to cultures for diagnosing invasive candidiasis, but their clinical roles are unclear. We propos...

Experience with β-d-Glucan Assay for Diagnosis of Invasive Candidiasis in ICU Patients: Pilot Study from India

Utility of Serial β-d-Glucan Levels in Patients with High Risk for Invasive Candidiasis: A Potential Tool for Antifungal Stewardship